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KMID : 0191120220370230195
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Journal of Korean Medical Science
2022 Volume.37 No. 23 p.195 ~ p.195
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One Autopsy Proved Neocortical Lewy Body Disease Without the Involvement of the Olfactory Bulb and Brainstem
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Chung Eun-Joo
Cho Hwa-Jin
Hur Dae-Young
Kim Yeong-Seok
Lee Kyung-Hwa
Kim Sang-Jin
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Abstract
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Lewy bodies (LBs) and Lewy neurites (LNs) are pathological hallmarks of Parkinson’s disease (PD) or dementia with LBs (DLB). Incidental Lewy body disease (iLBD) is defined when LBs and LNs are found in the brain of normal elderly individuals. A 65-year-old man presented with autopsy-proven Lewy body pathology (LBP). He had never complained of cognitive impairments or parkinsonian motor symptoms, and he had always maintained independence in activities of daily living. Hypopigmentations in the locus coeruleus and substantia nigra were discovered during the autopsy. The patient showed severe-to-extremely severe LBs in the neocortex and limbic areas, except in the nucleus basalis of Meynert, amygdala, and brainstem, according to microscopic findings. Hence, using several of the previously known staging systems, it was difficult to classify the patient’s LBP type. Furthermore, these findings were unique because they had never been observed before in iLBD.
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KEYWORD
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Incidental Lewy Body Disease, Parkinson Disease, Lewy Body Dementia, Lewy Bodies, Lewy Neurites, Synucleinopathies
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